Viruses use autoimmunity for immune camouflage

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PROJECT DESCRIPTION

Recent cutting edge advancements in Single Cell studies has revolutionised the research approach to understanding vaccine efficacy and autoimmunity. Our research group is utilizing state-of-the-art single T and B cell sequencing, with accompanying computational genome analyses, to understand the characteristics of these cells. T and B cells have an important role in driving vaccine induced protection and also autoimmune disease. Sometimes overlap develops between pathogen induced immune responses and autoimmunity resulting in either failed vaccine protection or autoimmunity. By understanding the mechanisms that drive this overlap it will enable us to improve vaccine efficacy and help combat the development of autoimmunity.

IDEAL CANDIDATE

This project is ideally suited to a researcher that wishes to develop interdisciplinary skills in viral immunology and autoimmunity. The immunological skills that the candidate will learn are high-dimensional flow cytometry for both T and B cells and cutting-edge immunodiagnostics of autoimmunity. A basic background in human biology and some laboratory skills in either molecular biology or immune-assays is advantageous. Ideally the candidate will be highly motivated and willing to expand on their current skills to enable a multi-disciplinary assay approach to study the immune correlates of protection, tolerance and autoimmunity. The candidate should have excellent communication skills and enjoy working as a team, as the interdisciplinary approach to our studies will require the candidate to work closely with a diverse range of professionals, including lab scientists, clinicians, mathematicians and computer scientists.
Supervisory team
Rowena
Bull

Medicine
Medical Sciences
Nicodemus
Tedla

Medicine
Medical Sciences
Fabio
Luciani

Medicine
Medical Sciences
r.bull@unsw.edu.au