Sex hormone synthesis at the ocular surface and in tear film

Back to search results
PROJECT DESCRIPTION

The tear film maintains a healthy transparent eye surface, enabling light to reach retina, ensuring clear vision. Precise control of tear film composition is essential, but how this occurs is incompletely known. We hypothesise that sex hormones control tear film production in humans, specifically production of tear lipids by meibomian glands in the eyelid. This project utilises ultrasensitive MS techniques pioneered by our team, to measure sex hormones in human meibomian gland cells, tissue samples, and in tears. This new knowledge will help develop novel treatments for painful sight-threatening diseases of the eye surface, with impact beyond the eye field.

IDEAL CANDIDATE

The ideal candidate will have:
- A background in analytical chemistry and hands-on experience in mass spectrometry. Specific experience in LC-MS/MS, particularly involving LC at capillary or nano scale, is very desirable. Experience in GC-MS/MS desirable but not essential. Experience with solid phase extraction (SPE) and Liquid-Liquid extraction techniques for preparation of biological samples is desirable.
- Some knowledge of experimental design, statistical analysis.
- Evidence of excellent verbal and written communication skills, preferably demonstrated by authorship of high impact scientific publications and international conference presentations.
- High level attention to detail and demonstrated capability to produce high quality research.
- Demonstrated high level of self-motivation and evidence of proactive behaviour.
- Willingness to collaborate generously, share knowledge and ability to work well in a team.
- Some experience of student supervision and/or teaching.
Supervisory team
Fiona
Stapleton

Science
Optometry and Vision Science
Blanka
Golebiowski

Science
Optometry and Vision Science
Martin
Bucknall

Mark Wainwright Analytical Centre, UNSW Division of Research
UNSW Bioanalytical Mass Spectrometry Facility
b.golebiowski@unsw.edu.au