Sex hormone regulation of tear-film production by human meibomian glands

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PROJECT DESCRIPTION

The tear film is essential to eyesight. It protects and nourishes the eye surface to maintain transparency to enable light to reach the retina. To guarantee these functions, exquisite control of tear film composition is required. We hypothesise that sex hormones control production of tear film in humans, and specifically production of tear lipids by the meibomian glands ofthe eyelid. This project utilises human cell culture models to examine potential mechanisms of tear film regulation by sex hormones. New knowledge generated will inform development of novel treatments for painful sight-threatening diseases of the eye surface, including dry eye.

IDEAL CANDIDATE

The ideal candidate for this project will have:
- A demonstrated interest in eye health.
- A background in cell biology and molecular biology laboratory techniques is very desirable. This includes practical and recent experience in mammalian tissue culture applications including co-culture and 3D culture techniques. Experience in establishing and maintaining primary human cell cultures is also desirable but not essential.
- Some knowledge of experimental design and statistical analysis.
- Evidence of excellent verbal and written communication skills, preferably demonstrated by authorship on a high impact scientific publications and international conference presentations.
- High level of attention to detail and demonstrated capability to produce high quality research outcomes.
- Demonstrated high level self-motivation and evidence of proactive behaviour.
- Willingness to collaborate generously, share knowledge and ability to work well in a team.
- Experience of student supervision and/or teaching is desirable.
Supervisory team
Blanka
Golebiowski

Science
Optometry and Vision Science
Michele
Madigan

Science
Optometry and Vision Science
Debarun
Dutta

Aston University
Aston Optometry School, Life and Health Sciences
b.golebiowski@unsw.edu.au