Non-spherical polymer nanoparticles and their behaviour in drug delivery

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PROJECT DESCRIPTION

Non-spherical polymer particles are widely proposed as superior drug delivery carriers. However, there is little understanding on the differences between round and elongated nanoparticles in a biological setting. In this project, we want to synthesise polymer nanoparticles of different shapes and test the flow of these nanoparticles in a simulated biological setting. Together with other researchers, we will build a flow system that is modified with mammalian cells to create a simple organ on a chip system that will help future researchers to identify the relation ship between polymer nanoparticles structure and their biological properties.

IDEAL CANDIDATE

The ideal candidate has a solid knowledge in polymer synthesis and characterisation. The candidate is required to prepare non-spherical nano-particles using latest polymer synthethis techniques, but the candidate should also have an interest in scattering techniques such as SAXS and SANS in a flow system. The student will spend some time at ANSTO and the Australian Synchrotron. It is desirable that the candidate has already worked in a biological lab or has interest in acquiring some skills in this area as we would like to understand how nanoparticles behave when in contact with mammalian cells such as cancer cells. The ideal candidate is comfortable working in a interdisciplinary team that covers areas from polymer synthesis and polymer physics to nanoparticles flow and up to biological studies.
Supervisory team
Martina
Stenzel

Science
Chemistry
Patrick
Spicer

Engineering
Chemical Engineering
Pall
Thordarson

Science
Chemistry
m.stenzel@unsw.edu.au