Epigenetic profiling of relapse-initiating cells in paediatric acute leukaemia

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PROJECT DESCRIPTION

Acute lymphoblastic leukaemia (ALL) is the most common childhood cancer and remains one of the most common causes of death from disease in children. Even though current treatments are effective in treating ALL, a small fraction of ALL cells may still survive after treatment. The cells that survive, even if only a single cell, can cause recurrence of ALL with low survival rates. This project aims to: (1) define fundamental epigenetic mechanisms of drug resistance; (2) use cutting edge single-cell technology to identify and eliminate cells causing relapse in ALL.

IDEAL CANDIDATE

Applicants should hold a scientific Degree with Honours or equivalent degree in biomedicine or related area, with some experience in cell/tissue culture and molecular biology techniques. This individual needs to be enthusiastic, flexible, be able to multitask, keen to learn and develop all aspects of the role and play an integral part in the research team. Other requirements include:
• Interest in the field of Cancer Research.
• Solid knowledge and experience working within a laboratory environment.
• Willingness to learn new laboratory techniques. Additional training in molecular biology techniques such as immunoprecipitation, cloning, sequencing, and gene modification etc. will be provided.
• Ability to interpret and communicate results to the supervisor and research group.
• Ability to plan and conduct experiments and work independently and or as a member of a team.
• Excellent organisational and time management skills.
• Exhibits a high degree of professionalism and respect for others.
Supervisory team
Richard
Lock

Medicine
Women's & Children's Health
John
Pimanda

Medicine
Medical Sciences
Duohui
Jing

Medicine
Women's & Children's Health
Richard.Lock@unsw.edu.au