Dissecting the role of endoplasmic reticulum stress in cancer progression

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PROJECT DESCRIPTION

Drug resistance to current cancer therapeutics and cancer metastasis is a major clinical problem that accounts for 90% of cancer-related deaths. Understanding the processes that lead to drug resistance and metastasis is critical for the development of effective drugs and novel therapeutic strategies.

This project dissects the mechanism by which the pathways of the Endoplasmic Reticulum (ER) modulates cancer progression, drug resistance and metastasis. Moreover, these ER signals can be transmitted between cancer cells and cancer-associated helper cells, including immune and stromal cells. Considering the importance of cancer-stromal cross-talk in cancer, studies will also elucidate the functional significance of this transmission for the first time.

IDEAL CANDIDATE

An ideal candidate is passionate about cancer research, particularly in the field of pancreatic and brain cancer. Preferably, the prospective candidate will have research experience, including a minimum of an honours degree with class I, an outstanding academic record, laboratory experience, community involvement and excellent communication skills.
Supervisory team
Angelica
Merlot

Medicine
Women's & Children's Health
Murray
Norris

Medicine
Women's & Children's Health
Minoti
Apte

Medicine
Other
a.merlot@unsw.edu.au