Boosting fetal globin expression to treat inherited blood disorders

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PROJECT DESCRIPTION

Mutations that affect the blood protein haemoglobin or its production are the most common single gene defects known. The individual and societal costs are enormous and disproportionately affect developing nations. Studies in human genetics have revealed that elevation of fetal globin effectively treats the disease. In this project we will use new CRISPR-gene editing technologies to investigate the regulation of the fetal globin gene and to boost fetal globin production.

IDEAL CANDIDATE

The ideal candidate would be someone who has an interest and training in haematology and experience in molecular biology.
Supervisory team
Merlin
Crossley

Science
Biotechnology & Biomolecular Sciences
Kate
Quinlan

Science
Biotechnology & Biomolecular Sciences
Tracey
O'Brien

Medicine
Women's & Children's Health
m.crossley@unsw.edu.au